The proactionary framework is for actors, not critics. It emphasizes our role as creators.
The proactionary framework adopts assumptions often seen as "the way it is." This framework includes ethical obligations, including the obligation to engineer a better future for our world. While we must be cautious, we cannot be General McClellan's. We must attack problems like childhood disease.
The central dogma of one genetic code per biological system is breaking down. As we redefine our genetic identities, we increase the threat of physical harms.
Synthetic biology may be less risky from a continuity perspective, but it also has the potential to be less predictible, and we may create synthetic biological systems that replicate out of control. See grey goo.